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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd4386a1d480760a0cec207ab159fac449aa28e61a9b67da3e3959a49317febc4' 
  AND token = 'y9HZShSNP0knELvNlE/injy67FnX0SS2a84z8k+ZvBM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}