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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '219b4904bf862e8a77b0d040acab8e2cb9c15502ea6652b6a4e3777d0718c645' 
  AND token = 'uFTyD9a22meGQc0CbvKCUKgdegvupMmTMDscgbrUV6o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}