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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6755a26439c591ead9997a4fbbf13596ed054ff840f6e0238f07d12302a62274' 
  AND token = 'pEO9U3tcizzuD0iTH1B428E9rFXvpUS1ihAYsiTtDlE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}