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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b44d293a90f3a6a666613ed617d86db8dd6c9de33300e8b1cdc66ea5dc15c280' 
  AND token = 'OyjLynPtnDne7Af/SRIK9QBaf/ixPqFxJ/7u0PnvWMM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}