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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af6860ccccbaac5acd9a86cd420d5ceb25c34e8e22001880ca1cc75a60459770' 
  AND token = '+rsrX5iTSprel2WodU4lI++n+5nN1DS0G285u9WMuKQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}