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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9a493e850f97c9861814b6117b7daa28d181d8c6c68f169a4a02bdaa86f98e6d' 
  AND token = 'UD0P47Z+hkVLOmBnn330WRbQZvp5OW3+pFUCIT50aE4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}