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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c65e38c0195104aac156862e9dde9250bd0158e2e29327242e98bf4cfea6208c' 
  AND token = 'RZYtWp7qExVxfZQUW+Za0I7RNlLBX9nAFnrDrhFsTP4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}