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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ad3000e3e64fd42de104c222a61d0436b99337e54677caf1e1c82448a1d0e9f' 
  AND token = '7qPO3eI5kjErBXeGS2ZRn9tCeVJkjpfl1Qu9qXwF1M0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}