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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8fa58a99474c3f54fdb440e31dacdd49eee49058f78ece7a1acea3fbb3f43c4' 
  AND token = 'ty0IGEglW/kDm+cIn0XAAY6mU5wRjm11rSFRNRbSByE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}