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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2cf793191975ca640b22c988e07f00edbcc3a20983804da2972c80c88edfefb3' 
  AND token = 'LyZy+UxGlr6Sdkik0PpG3xK2zHkuZeak6U7avu+MOLg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}