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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '330a53d4a77014d7a5c07a5946a4da6fae58be6c0a1fd51d600bbf40b6344f2c' 
  AND token = 'pSyOXjfuhfGuE+f4fT48Q3XEBUNa+8SCj86Tq5EYI/8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}