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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fb954f61db0362ee3dfb380016be5ea4e3244bd18f3571450349135b3e0c0868' 
  AND token = 'skv+s7GiH+iu8kmc/EU0G7BX6wbbvV8YF9KTQ45zFSs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}