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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '759393ba247d0eabb35d84a871424711740e4e249e3552b5ccc14e9fa06b2416' 
  AND token = 'y4t6AidOQmn+cywqijI+VF3EBLvdPThzwdmi0TXFqPQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}