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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '165149635ee293c76e6fa4313ac0a74e3a21f58e2bc20bcb100600ced17c4ed7' 
  AND token = 'EsE22QaMymm4GhFPxvsmjqBSZ0EPspmUwiLGH1vr9TM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}