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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22d642143c05a9c47e44e85186032a97302de7db76fb82c32016d29387a3340e' 
  AND token = '1oZq7fgwpkP+4d54W8UZZYSjUMil1YbZhCjoss95AW8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}