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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1506e420737290077eee29281a7ed5aba727cb5041ec232a1b3d8a3a3ebb1482' 
  AND token = 'Dz5FYiDuGdufzLB6UEMFEO7D+7KzigmwRo9tb3WRmcI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}