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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6cc19da3b81b4e7cfcc2855089d209f04d60a97d89f3dde15699a6be8c158556' 
  AND token = '1UgVo0ZHKZ3DIsCXQFe9MnG0gjuhFXguiA8Ys5sDBHI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}