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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c301fe39817b82f423d76525d76d2b1b311a7ec30e3682a5f5ef65a810f2a4be' 
  AND token = 'F6vx5Xw4KKOcQGRz+e4tETtvVwxfrSlupgix+rBzExw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}