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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222580f033c786d3f2496d84a8ffe7b69928df0b148e907d323ae967ae85b062' 
  AND token = 'xDT6xHFsN8KM3owhLxKWO5oHvCyEc4nMuRPHnKub0K0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}