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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '781bfd6a132b8aad599f6f27d816e523079e6e3d9e1c3895d0906302e0ce4b4d' 
  AND token = 'jIzK6Bnc6BFlTUl0w2E/5mzBP/Fa++oFIxMk5OrLdiU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}