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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'da78ac53c04b98fb58edcffbd44446f639981fc649792e32173e9b73a2ea20e9' 
  AND token = '+p/1rjnbXesxC4Gcfex+yVDCtAygYvRyaksgGru2zEk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}