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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '781451385a2abebeaa808061172d24198d4e6ba096f98677d250d27275c2bb67' 
  AND token = 'O7c/aHG99Av9Is+E+29sbs7guj1z/njYNqHJzHEJ8zc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}