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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5ac543d81072f3012aec863d324962f2ae6942acd3ab53e9f646d9f04e715d4e' 
  AND token = 'TSynUBIq2sQ+gkcYxlYQxlxW7E/WbtDBstTvRrI1BSk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}