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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '27ed1914316e207d8e7b977f727a1a2ffe2589f5c012b934602028d15940b4b7' 
  AND token = 'JWFI97++uVL8MBbi25+pj9BP0+pnJzH4VD3t9B0VOrY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}