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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e78f332e8db2a86203c881eb1903bde8fa605b890be1226d3d2e728b50c2d57' 
  AND token = 'RWbAIP9K72Fq/k8amVesHarrGki/GWG5/cp7jN5OzIc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}