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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a7776dc9356aa74f6b9273b1b5809d4b16b555ebcb92a1da17b1c488e1792af' 
  AND token = 'EwhwzdTE4JmTS+a/ZgEmxrn32Oiadok/nT3K7tg+E4I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}