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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd183c3234a030920cd2878c27447565b7edb5e412baa039448c508da6053c5e1' 
  AND token = 'Ji2dBHYHsCmf9uj61O780VnH2oZfN6wtU4D81iMZiaU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}