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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '38292249c3807eae92241af2aa44451b39ff229027fd6571f8dacaa2010d6f5b' 
  AND token = 'it4NUE+Yayc2N+/a/33MSg7y65Bpa0A/+U/pWLZTMpg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}