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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6105457b4413127065fa052d37fb6eb7e22294e89a4780bf34a301e38589a6a8' 
  AND token = 'nwQCBjWQGGkvszm0PQcQUcCN6NkoI0HKy591Y/4BAzs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}