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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2efaee7fc5ec22131b268a0a54e29e2ea9734dd164e5335267b6e4ed91877262' 
  AND token = 'rTcXPy0tGhgc8iwQixoQ2sBG7V2e5dUP3IBK1gOoiD4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}