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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2104296f73c12411d12948c769cbd4486eaffb65f2bc2e46dc6f5fc6a443359f' 
  AND token = 'aFf/IMR1qHAVPHCyST2rl+5Zw3vUHV3L4nmrYqvxTVE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}