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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0427aefa5d86396f2054a034f43cbab8e0a0aadf5c97d0ed68716f57c90926c8' 
  AND token = 'K6CkRHjt3K8Hf6TLFuBFaemMunapAQyCcyvkaLJ33V8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}