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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33a7b1e76a33922fae180d0f82c54e0a837b07faa9509bdca2325c333b52e63a' 
  AND token = 'JZ8PYZPc/J9Yb2e8CVguVG/yNaAADhWe8V+Kt0KCpxA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}