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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e07ed2c8c0d55da418b087e3c70280b973b7c21d8747347d1504036f6f476c66' 
  AND token = 'hZGzFNOAv9Ey8bXoVzTHBK8j2yZenf4zdaVUxYE7Q1I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}