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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b21dcafe57182f702455151148a0b98d89bc8a731b51ba09155eafe227b72ac' 
  AND token = 'w9rFgbzlkBbOTwjK/ZZ+MTBDJV1sof5r9vEIzTlNw1g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}