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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7784ec4018b80db6e35a855f1dbcd4fb0bbd9bea9ecc897f2f8cfe018f19a467' 
  AND token = 'e110qbTF2Ao1UCGnFW+DMW7Ro872459TWFVy4qYSVI0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}