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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '273180ce403fbd0c032de74ac4d14b7ecf4cab3bf21e0b2fb161806b502f1716' 
  AND token = 'qyo20Ouvm7IY078IG2ibC088Zv/zTAcR4FWPrEbosmU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}