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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9cd56783b2d8b73d77df8cd7261912f0722c31755de25b1c38218df4c1f590ba' 
  AND token = 'iUPiK/MkiF8Jrj/EpPOH+fBlBikExkpSF8bSVzkGGoc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}