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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a49cd484449aa585944105cbac0ecdf3901ac54543d7049b88de11420565e678' 
  AND token = 'cKi2EyDdX1giptzUJfymxy+eICogWzA3SMbi4Hioeuc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}