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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e74469a529a5b310608dba912ef1b999f50cb78d81ca35da2229f5701018539' 
  AND token = '9oV10QPFF1htC+k4GhLemnzO8cdUH1qTIjjGRHTZfp4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}