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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd0b1a113c416de3e69c3be55e32617da6c1e5af02b0bf9375a08182b328722c1' 
  AND token = 'uJ00tcgF6ku9p5cOuOLREX3RNiN1fB0OgSCwJb4Gwgw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}