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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '080d4e8c8bd0c641ec5a010364b280a02a72146694d6547b1d2e2ead720c4635' 
  AND token = 'y/hem/FmV3ZASwCr/xPgbBviSq2zHWwr3W6E+fP5zmc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}