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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '269a86f610eade1c6c662eed93e9734bce71f84bba03b8d68696dec8259eb4b1' 
  AND token = 'EQkd2/wPRmLdLo5d7LZPxQ7OrNgMjE3GYXHMqLjBASc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}