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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '741b0e464b548db58363c733312d4de6606c2a1fc48c96bca1d31370e6c82f22' 
  AND token = 'UcR5E3b+QpZ7/cGxqXjQgWQe6xUjMJteJkQM4AD1b9M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}