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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '465d5457641ebde911c6f0f6d2d6531b6d58e4adaa3c33e7b5441be04fc1949f' 
  AND token = 'H3B6VamII4qhNLxCrLK1TMx9NxcPGFhIqqj1jccjfGI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}