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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '40c8d30a42f76931e2055bacf620a1390bf538b54f7b7324ade46df93401af72' 
  AND token = 'TrVMJ4VuXR9aOsZKoGX9E1aYUtaAr5VFm+OzCbLk/FM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}