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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ab1d58541a9bebe01e347281219c1bf018de975384cf7dc3f282b245f4b7b2c' 
  AND token = 'cOZOTgh+OUuPgH3lhLc6sJF1hOA/CCRix2H2lvBCh/4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}