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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b4271b59785f1c503d0061c2202db5b1a4984794ced2bf43d110258e356c5a78' 
  AND token = 'lw3Blt0hExXbFDYhPFDfa8Dk8piwMOzLtatuijdDZ1w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}