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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1ca4fc73a3c3890797dacbc96c7944516030e0fcf9054d822355984314c2b474' 
  AND token = 'mdBY3+jGZ/cNQTGGxOi1lamcz5khR35EzVeA4DlLd1c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}