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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e1cdaf6494edaa99fde5c00d19c48e364fde6330cc1f21160aee41a19f434f2' 
  AND token = 'OHb7DAGiwARVL3B3o/5jAxkeiB5X8NjnHstdfs2EQkI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}